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Table 4: Mean serum gliclazide concentration (ng/ml) before and after oral administration of pravastatin in normal rabbits ($n=5$).

Time (h) Gliclazide Gliclazide + pravastatatin (acute) Gliclazide + pravastatatin (chronic) 0 0 0 0 1 $98.54\pm 06.29$ $116.4\pm {03.43}^{†}$ $121.9\pm {08.60}^{‡}$ 2 $246.6\pm 10.54$ $168.7\pm {03.58}^{†}$ $178.3\pm {06.60}^{†}$ 3 $343.4\pm 11.54$ $393.7\pm {07.31}^{†}$ $396.1\pm {17.57}^{‡}$ 4 $294.8\pm 12.19$ $294.6\pm 06.55$ $301.8\pm 07.39$ 6 $261.2\pm 09.03$ $312.8\pm {04.56}^{*}$ $316.7\pm {09.81}^{*}$ 8 $222.3\pm 07.33$ $342.3\pm {15.80}^{*}$ $343.8\pm {08.12}^{*}$ 12 $151.1\pm 09.34$ $264.5\pm {06.02}^{*}$ $259.7\pm {07.58}^{*}$ 18 $105.1\pm 06.59$ $108.1\pm 02.76$ $112.5\pm 06.24$ 24 $74.09\pm 02.22$ $96.43\pm {01.74}^{*}$ $98.46\pm {06.27}^{‡}$

${}^{*}$Significant at $P<.001$; ${}^{†}$Significant at $P<.01$; ${}^{‡}$Significant at $P<.05$ compared to gliclazide control.