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Table 2: The 20 most upregulated ribosome biogenesis genes in CRC compared to matching normal mucosa. Values represent log2 differences between the median of tumor samples and normal mucosa. Those genes that, in MSS specimens, localized to chromosomal areas with possible gene-dosage contribution to overexpression are italic. The number of binding sites per TF is indicated in brackets. * MYCN is not detected in our CRC microarray profiling analysis.

Gene Chromosomal location Log 2 T-N NRF1 ELK1 HIF1A $\text{M}\text{Y}\text{C}{\text{N}}^{*}$ EXOSC5 19q13.1 3.20 X(1) X(1) X(3) X(2) RUVBL1 3q21 2.53 — — — X(1) NOC4L 12q24.33 2.47 X(1) — X(2) X(1) BOP1 8q24.3 2.45 X(2) — X(2) X(1) RRP9 3p21.1 2.44 X(1) X(1) — X(1) RRS1 8q13.1 2.40 — X(1) — X(1) BYSL 6p21.1 2.37 — — — — NOL1 2p25.1 2.36 X(1) — — X(1) TBL3 16p13.3 2.33 — — X(1) — WDR74 11q12.3 2.25 — — — — RRP1 21q22.3 2.16 X(4) — X(1) — DKC1 Xq28 2.12 X(3) — X(1) — DDX56 7p13 2.00 — — — — EXOSC4 8q24.3 1.94 — — — — PPAN 19p13 1.93 — — — — CGI-96 22q13.2-q13.31 1,92 X(1) — — — POLR2E 19p13.3 1,90 X(1) — — — MRTO4 1p36.13 1,86 — — — NOC2L 1p36.33 1,85 X(2) X(1) X(2) — SURF6 9q34.2 1,82 — X(2) X(1) X(2)