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Volume 2008 (2008), Article ID 360572
doi:10.3814/2008/360572
Research Article

HomoSAR: An Integrated Approach Using Homology Modeling and Quantitative Structure-Activity Relationship for Activity Prediction of Peptides

Department of Pharmaceutical Chemistry, Bombay College of Pharmacy, Kalina, Santacruz (E), Mumbai 400098, India
  • Received 2008-03-24
  • Revised 2008-08-04
  • Accepted 2008-08-12

Reviewer Evaluations

The journal employs a transparent peer review system in which the evaluations of the reviewers are published along side the accepted articles. The reviewer evaluations and optional commentaries for the current article are given below.

V. M. Kulkarni
Bharati Vidyapeeth University, India
Posted on 2008-08-11

The 3D-QSAR methods have continued to be useful tools, even though as in the present case, the alignment of molecules is shifted from 3D space to 1D space. The HomoSAR, based on the principles of homology modeling, which has helped authors to design and predict affinities (Table 3) need further validation by experimentation. The HomoSAR could be an useful research tool in peptidic drug design. Good work.

R. P. Iyer
Spring Bank Technologies, Inc., USA
Posted on 2008-08-11